AustralieFrV1, Main, Exploration, bibRecord, 000504

Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection: a randomised, double-blind, parallel-group, phase 3, non-inferiority trial.

Identifieur interne : 000504 ( Main/Exploration ); précédent : 000503; suivant : 000505

Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection: a randomised, double-blind, parallel-group, phase 3, non-inferiority trial.

Auteurs : Pedro Cahn [Argentine] ; Richard Kaplan [Afrique du Sud] ; Paul E. Sax [États-Unis] ; Kathleen Squires [États-Unis] ; Jean-Michel Molina [France] ; Anchalee Avihingsanon [Thaïlande] ; Winai Ratanasuwan [Thaïlande] ; Evelyn Rojas [Guatemala] ; Mohammed Rassool [Afrique du Sud] ; Mark Bloch [Australie] ; Linos Vandekerckhove [Belgique] ; Peter Ruane [États-Unis] ; Yazdan Yazdanpanah [France] ; Christine Katlama [France] ; Xia Xu [États-Unis] ; Anthony Rodgers [États-Unis] ; Lilly East [États-Unis] ; Larissa Wenning [États-Unis] ; Sandy Rawlins [États-Unis] ; Brenda Homony [États-Unis] ; Peter Sklar [États-Unis] ; Bach-Yen Nguyen [États-Unis] ; Randi Leavitt [États-Unis] ; Hedy Teppler [États-Unis]

Source :

The lancet. HIV [ 2352-3018 ] ; 2017.

RBID : pubmed:28918877

Abstract

Once daily regimens are preferred for HIV-1 treatment, to facilitate adherence and improve quality of life. We compared a new once daily formulation of raltegravir to the currently marketed twice daily formulation.

DOI: 10.1016/S2352-3018(17)30128-5
PubMed: 28918877

Affiliations:

Afrique du Sud, Argentine, Australie, Belgique, France, Guatemala, Thaïlande, États-Unis
Californie, Massachusetts, New Jersey, Pennsylvanie, Île-de-France
Paris

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection: a randomised, double-blind, parallel-group, phase 3, non-inferiority trial.</title>
<author><name sortKey="Cahn, Pedro" sort="Cahn, Pedro" uniqKey="Cahn P" first="Pedro" last="Cahn">Pedro Cahn</name>
<affiliation wicri:level="1"><nlm:affiliation>Fundación Huesped, Buenos Aires, Argentina.</nlm:affiliation>
<country xml:lang="fr">Argentine</country>
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<author><name sortKey="Kaplan, Richard" sort="Kaplan, Richard" uniqKey="Kaplan R" first="Richard" last="Kaplan">Richard Kaplan</name>
<affiliation wicri:level="1"><nlm:affiliation>Desmond Tutu HIV Foundation, Cape Town, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Desmond Tutu HIV Foundation, Cape Town</wicri:regionArea>
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<author><name sortKey="Sax, Paul E" sort="Sax, Paul E" uniqKey="Sax P" first="Paul E" last="Sax">Paul E. Sax</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
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<wicri:regionArea>Brigham & Women's Hospital, Harvard Medical School, Boston, MA</wicri:regionArea>
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</placeName>
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<author><name sortKey="Squires, Kathleen" sort="Squires, Kathleen" uniqKey="Squires K" first="Kathleen" last="Squires">Kathleen Squires</name>
<affiliation wicri:level="2"><nlm:affiliation>Thomas Jefferson University, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Thomas Jefferson University, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
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<author><name sortKey="Molina, Jean Michel" sort="Molina, Jean Michel" uniqKey="Molina J" first="Jean-Michel" last="Molina">Jean-Michel Molina</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Saint-Louis Hospital, APHP, University of Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Avihingsanon, Anchalee" sort="Avihingsanon, Anchalee" uniqKey="Avihingsanon A" first="Anchalee" last="Avihingsanon">Anchalee Avihingsanon</name>
<affiliation wicri:level="1"><nlm:affiliation>HIV-NAT, Thai Red Cross AIDS Research Center and Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
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<wicri:noRegion>Bangkok</wicri:noRegion>
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<author><name sortKey="Ratanasuwan, Winai" sort="Ratanasuwan, Winai" uniqKey="Ratanasuwan W" first="Winai" last="Ratanasuwan">Winai Ratanasuwan</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
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<wicri:noRegion>Bangkok</wicri:noRegion>
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<author><name sortKey="Rojas, Evelyn" sort="Rojas, Evelyn" uniqKey="Rojas E" first="Evelyn" last="Rojas">Evelyn Rojas</name>
<affiliation wicri:level="1"><nlm:affiliation>Cericap Multiclinicas, Edifico Galerías, Guatemala City, Guatemala.</nlm:affiliation>
<country xml:lang="fr">Guatemala</country>
<wicri:regionArea>Cericap Multiclinicas, Edifico Galerías, Guatemala City</wicri:regionArea>
<wicri:noRegion>Guatemala City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rassool, Mohammed" sort="Rassool, Mohammed" uniqKey="Rassool M" first="Mohammed" last="Rassool">Mohammed Rassool</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Witwatersrand, Helen Joseph Hospital, Johannesburg, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
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</author>
<author><name sortKey="Bloch, Mark" sort="Bloch, Mark" uniqKey="Bloch M" first="Mark" last="Bloch">Mark Bloch</name>
<affiliation wicri:level="1"><nlm:affiliation>Holdsworth House Medical Practice, Sydney NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Holdsworth House Medical Practice, Sydney NSW</wicri:regionArea>
<wicri:noRegion>Sydney NSW</wicri:noRegion>
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<author><name sortKey="Vandekerckhove, Linos" sort="Vandekerckhove, Linos" uniqKey="Vandekerckhove L" first="Linos" last="Vandekerckhove">Linos Vandekerckhove</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Faculty of Medicine and Health Sciences, University of Ghent, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruane, Peter" sort="Ruane, Peter" uniqKey="Ruane P" first="Peter" last="Ruane">Peter Ruane</name>
<affiliation wicri:level="2"><nlm:affiliation>Ruane Medical & Liver Health Institute, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ruane Medical & Liver Health Institute, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name>
<affiliation wicri:level="3"><nlm:affiliation>Hôpital Bichat-Claude Bernard, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Bichat-Claude Bernard, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
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<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Katlama, Christine" sort="Katlama, Christine" uniqKey="Katlama C" first="Christine" last="Katlama">Christine Katlama</name>
<affiliation wicri:level="3"><nlm:affiliation>Hôpital Pitié-Salpêtrière Pavillon Laveran, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Pitié-Salpêtrière Pavillon Laveran, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Xia" sort="Xu, Xia" uniqKey="Xu X" first="Xia" last="Xu">Xia Xu</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodgers, Anthony" sort="Rodgers, Anthony" uniqKey="Rodgers A" first="Anthony" last="Rodgers">Anthony Rodgers</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="East, Lilly" sort="East, Lilly" uniqKey="East L" first="Lilly" last="East">Lilly East</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wenning, Larissa" sort="Wenning, Larissa" uniqKey="Wenning L" first="Larissa" last="Wenning">Larissa Wenning</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rawlins, Sandy" sort="Rawlins, Sandy" uniqKey="Rawlins S" first="Sandy" last="Rawlins">Sandy Rawlins</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Homony, Brenda" sort="Homony, Brenda" uniqKey="Homony B" first="Brenda" last="Homony">Brenda Homony</name>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
</affiliation>
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<author><name sortKey="Sklar, Peter" sort="Sklar, Peter" uniqKey="Sklar P" first="Peter" last="Sklar">Peter Sklar</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nguyen, Bach Yen" sort="Nguyen, Bach Yen" uniqKey="Nguyen B" first="Bach-Yen" last="Nguyen">Bach-Yen Nguyen</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leavitt, Randi" sort="Leavitt, Randi" uniqKey="Leavitt R" first="Randi" last="Leavitt">Randi Leavitt</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Teppler, Hedy" sort="Teppler, Hedy" uniqKey="Teppler H" first="Hedy" last="Teppler">Hedy Teppler</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA. Electronic address: hedy_teppler@merck.com.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection: a randomised, double-blind, parallel-group, phase 3, non-inferiority trial.</title>
<author><name sortKey="Cahn, Pedro" sort="Cahn, Pedro" uniqKey="Cahn P" first="Pedro" last="Cahn">Pedro Cahn</name>
<affiliation wicri:level="1"><nlm:affiliation>Fundación Huesped, Buenos Aires, Argentina.</nlm:affiliation>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Fundación Huesped, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaplan, Richard" sort="Kaplan, Richard" uniqKey="Kaplan R" first="Richard" last="Kaplan">Richard Kaplan</name>
<affiliation wicri:level="1"><nlm:affiliation>Desmond Tutu HIV Foundation, Cape Town, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Desmond Tutu HIV Foundation, Cape Town</wicri:regionArea>
<wicri:noRegion>Cape Town</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sax, Paul E" sort="Sax, Paul E" uniqKey="Sax P" first="Paul E" last="Sax">Paul E. Sax</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham & Women's Hospital, Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Squires, Kathleen" sort="Squires, Kathleen" uniqKey="Squires K" first="Kathleen" last="Squires">Kathleen Squires</name>
<affiliation wicri:level="2"><nlm:affiliation>Thomas Jefferson University, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Thomas Jefferson University, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Molina, Jean Michel" sort="Molina, Jean Michel" uniqKey="Molina J" first="Jean-Michel" last="Molina">Jean-Michel Molina</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Infectious Diseases, Saint-Louis Hospital, APHP, University of Paris, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Infectious Diseases, Saint-Louis Hospital, APHP, University of Paris, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Avihingsanon, Anchalee" sort="Avihingsanon, Anchalee" uniqKey="Avihingsanon A" first="Anchalee" last="Avihingsanon">Anchalee Avihingsanon</name>
<affiliation wicri:level="1"><nlm:affiliation>HIV-NAT, Thai Red Cross AIDS Research Center and Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>HIV-NAT, Thai Red Cross AIDS Research Center and Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ratanasuwan, Winai" sort="Ratanasuwan, Winai" uniqKey="Ratanasuwan W" first="Winai" last="Ratanasuwan">Winai Ratanasuwan</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.</nlm:affiliation>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok</wicri:regionArea>
<wicri:noRegion>Bangkok</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rojas, Evelyn" sort="Rojas, Evelyn" uniqKey="Rojas E" first="Evelyn" last="Rojas">Evelyn Rojas</name>
<affiliation wicri:level="1"><nlm:affiliation>Cericap Multiclinicas, Edifico Galerías, Guatemala City, Guatemala.</nlm:affiliation>
<country xml:lang="fr">Guatemala</country>
<wicri:regionArea>Cericap Multiclinicas, Edifico Galerías, Guatemala City</wicri:regionArea>
<wicri:noRegion>Guatemala City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rassool, Mohammed" sort="Rassool, Mohammed" uniqKey="Rassool M" first="Mohammed" last="Rassool">Mohammed Rassool</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Witwatersrand, Helen Joseph Hospital, Johannesburg, South Africa.</nlm:affiliation>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>University of Witwatersrand, Helen Joseph Hospital, Johannesburg</wicri:regionArea>
<wicri:noRegion>Johannesburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bloch, Mark" sort="Bloch, Mark" uniqKey="Bloch M" first="Mark" last="Bloch">Mark Bloch</name>
<affiliation wicri:level="1"><nlm:affiliation>Holdsworth House Medical Practice, Sydney NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Holdsworth House Medical Practice, Sydney NSW</wicri:regionArea>
<wicri:noRegion>Sydney NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vandekerckhove, Linos" sort="Vandekerckhove, Linos" uniqKey="Vandekerckhove L" first="Linos" last="Vandekerckhove">Linos Vandekerckhove</name>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine and Health Sciences, University of Ghent, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Faculty of Medicine and Health Sciences, University of Ghent, Ghent</wicri:regionArea>
<wicri:noRegion>Ghent</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruane, Peter" sort="Ruane, Peter" uniqKey="Ruane P" first="Peter" last="Ruane">Peter Ruane</name>
<affiliation wicri:level="2"><nlm:affiliation>Ruane Medical & Liver Health Institute, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ruane Medical & Liver Health Institute, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name>
<affiliation wicri:level="3"><nlm:affiliation>Hôpital Bichat-Claude Bernard, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Bichat-Claude Bernard, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Katlama, Christine" sort="Katlama, Christine" uniqKey="Katlama C" first="Christine" last="Katlama">Christine Katlama</name>
<affiliation wicri:level="3"><nlm:affiliation>Hôpital Pitié-Salpêtrière Pavillon Laveran, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Pitié-Salpêtrière Pavillon Laveran, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Xia" sort="Xu, Xia" uniqKey="Xu X" first="Xia" last="Xu">Xia Xu</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodgers, Anthony" sort="Rodgers, Anthony" uniqKey="Rodgers A" first="Anthony" last="Rodgers">Anthony Rodgers</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="East, Lilly" sort="East, Lilly" uniqKey="East L" first="Lilly" last="East">Lilly East</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wenning, Larissa" sort="Wenning, Larissa" uniqKey="Wenning L" first="Larissa" last="Wenning">Larissa Wenning</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rawlins, Sandy" sort="Rawlins, Sandy" uniqKey="Rawlins S" first="Sandy" last="Rawlins">Sandy Rawlins</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Homony, Brenda" sort="Homony, Brenda" uniqKey="Homony B" first="Brenda" last="Homony">Brenda Homony</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sklar, Peter" sort="Sklar, Peter" uniqKey="Sklar P" first="Peter" last="Sklar">Peter Sklar</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nguyen, Bach Yen" sort="Nguyen, Bach Yen" uniqKey="Nguyen B" first="Bach-Yen" last="Nguyen">Bach-Yen Nguyen</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leavitt, Randi" sort="Leavitt, Randi" uniqKey="Leavitt R" first="Randi" last="Leavitt">Randi Leavitt</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Teppler, Hedy" sort="Teppler, Hedy" uniqKey="Teppler H" first="Hedy" last="Teppler">Hedy Teppler</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Inc, Kenilworth, NJ, USA. Electronic address: hedy_teppler@merck.com.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, Inc, Kenilworth, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The lancet. HIV</title>
<idno type="eISSN">2352-3018</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Once daily regimens are preferred for HIV-1 treatment, to facilitate adherence and improve quality of life. We compared a new once daily formulation of raltegravir to the currently marketed twice daily formulation.</div>
</front>
</TEI>
<affiliations><list><country><li>Afrique du Sud</li>
<li>Argentine</li>
<li>Australie</li>
<li>Belgique</li>
<li>France</li>
<li>Guatemala</li>
<li>Thaïlande</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Massachusetts</li>
<li>New Jersey</li>
<li>Pennsylvanie</li>
<li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
</list>
<tree><country name="Argentine"><noRegion><name sortKey="Cahn, Pedro" sort="Cahn, Pedro" uniqKey="Cahn P" first="Pedro" last="Cahn">Pedro Cahn</name>
</noRegion>
</country>
<country name="Afrique du Sud"><noRegion><name sortKey="Kaplan, Richard" sort="Kaplan, Richard" uniqKey="Kaplan R" first="Richard" last="Kaplan">Richard Kaplan</name>
</noRegion>
<name sortKey="Rassool, Mohammed" sort="Rassool, Mohammed" uniqKey="Rassool M" first="Mohammed" last="Rassool">Mohammed Rassool</name>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Sax, Paul E" sort="Sax, Paul E" uniqKey="Sax P" first="Paul E" last="Sax">Paul E. Sax</name>
</region>
<name sortKey="East, Lilly" sort="East, Lilly" uniqKey="East L" first="Lilly" last="East">Lilly East</name>
<name sortKey="Homony, Brenda" sort="Homony, Brenda" uniqKey="Homony B" first="Brenda" last="Homony">Brenda Homony</name>
<name sortKey="Leavitt, Randi" sort="Leavitt, Randi" uniqKey="Leavitt R" first="Randi" last="Leavitt">Randi Leavitt</name>
<name sortKey="Nguyen, Bach Yen" sort="Nguyen, Bach Yen" uniqKey="Nguyen B" first="Bach-Yen" last="Nguyen">Bach-Yen Nguyen</name>
<name sortKey="Rawlins, Sandy" sort="Rawlins, Sandy" uniqKey="Rawlins S" first="Sandy" last="Rawlins">Sandy Rawlins</name>
<name sortKey="Rodgers, Anthony" sort="Rodgers, Anthony" uniqKey="Rodgers A" first="Anthony" last="Rodgers">Anthony Rodgers</name>
<name sortKey="Ruane, Peter" sort="Ruane, Peter" uniqKey="Ruane P" first="Peter" last="Ruane">Peter Ruane</name>
<name sortKey="Sklar, Peter" sort="Sklar, Peter" uniqKey="Sklar P" first="Peter" last="Sklar">Peter Sklar</name>
<name sortKey="Squires, Kathleen" sort="Squires, Kathleen" uniqKey="Squires K" first="Kathleen" last="Squires">Kathleen Squires</name>
<name sortKey="Teppler, Hedy" sort="Teppler, Hedy" uniqKey="Teppler H" first="Hedy" last="Teppler">Hedy Teppler</name>
<name sortKey="Wenning, Larissa" sort="Wenning, Larissa" uniqKey="Wenning L" first="Larissa" last="Wenning">Larissa Wenning</name>
<name sortKey="Xu, Xia" sort="Xu, Xia" uniqKey="Xu X" first="Xia" last="Xu">Xia Xu</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Molina, Jean Michel" sort="Molina, Jean Michel" uniqKey="Molina J" first="Jean-Michel" last="Molina">Jean-Michel Molina</name>
</region>
<name sortKey="Katlama, Christine" sort="Katlama, Christine" uniqKey="Katlama C" first="Christine" last="Katlama">Christine Katlama</name>
<name sortKey="Yazdanpanah, Yazdan" sort="Yazdanpanah, Yazdan" uniqKey="Yazdanpanah Y" first="Yazdan" last="Yazdanpanah">Yazdan Yazdanpanah</name>
</country>
<country name="Thaïlande"><noRegion><name sortKey="Avihingsanon, Anchalee" sort="Avihingsanon, Anchalee" uniqKey="Avihingsanon A" first="Anchalee" last="Avihingsanon">Anchalee Avihingsanon</name>
</noRegion>
<name sortKey="Ratanasuwan, Winai" sort="Ratanasuwan, Winai" uniqKey="Ratanasuwan W" first="Winai" last="Ratanasuwan">Winai Ratanasuwan</name>
</country>
<country name="Guatemala"><noRegion><name sortKey="Rojas, Evelyn" sort="Rojas, Evelyn" uniqKey="Rojas E" first="Evelyn" last="Rojas">Evelyn Rojas</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Bloch, Mark" sort="Bloch, Mark" uniqKey="Bloch M" first="Mark" last="Bloch">Mark Bloch</name>
</noRegion>
</country>
<country name="Belgique"><noRegion><name sortKey="Vandekerckhove, Linos" sort="Vandekerckhove, Linos" uniqKey="Vandekerckhove L" first="Linos" last="Vandekerckhove">Linos Vandekerckhove</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection: a randomised, double-blind, parallel-group, phase 3, non-inferiority trial.

Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection: a randomised, double-blind, parallel-group, phase 3, non-inferiority trial.

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	Serveur d'exploration sur les relations entre la France et l'Australie
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